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JPM 2022: PacBio lets Google peek under the hood to help boost its long-read DNA sequencing accuracy – FierceBiotech



Fierce Biotech's JPM 2022 coverage all in one place
Dealmaking, R&D updates and biotech trends: Follow our coverage of the virtual JPM 2022
Pacific Biosciences will work with machine learning researchers at Google to bolster the accuracy of its DNA sequencing hardware.
It’s not the companies’ first collaboration. Pre-published work from last year showed Google’s artificial intelligence tools could increase the yields of PacBio’s long-read sequencing, already 99.9% accurate in some cases, by another 27% per instrument run.
“Traditionally, Google has been doing a lot of work on deep variants and looking at interpretation and back-end processing,” PacBio’s chief operating officer, Mark Van Oene, said during the company’s presentation at the J.P. Morgan Healthcare Conference. “This time, we’re having them focus on our raw base accuracy
“Something as small as a 2% increase in raw base accuracy with our traces could lead to a 20% increase in yield,” Van Oene said. “The goal here is to get them inside the system.” 
RELATED: PacBio snaps up DNA sequencing startup Omniome in deal worth up to $800M
The plan is to integrate Google’s deep learning tech into PacBio’s future products, specifically aimed at sharpening the hardware’s abilities in both whole genome and targeted sequencing applications.
“The more we can improve that accuracy, the more we will be able to drive down costs, increase throughput and help our customers resolve important biology,” said PacBio President and CEO Christian Henry.
Meanwhile at the conference, PacBio announced a pilot project with Genomics England to sequence biobanked samples from patients with rare diseases using the company’s HiFi technology.
The collaboration will reanalyze samples that had their DNA previously read by short-read sequencers—through the organization’s 100,000 Genomes Project—to see whether PacBio’s long-read machines can give a clearer picture of the patient’s genome and identify any additional clinically relevant mutations.
“The 100,000 Genomes Project was able to find actionable mutations in around 25% of patients with rare disease,” Parker Moss, Genomics England’s chief ecosystem and partnership officer, said in a statement. “We are excited to discover whether new technologies like PacBio’s HiFi can identify additional genomic variants in regions of the genome that are not readily accessible by short-read sequencing technologies.”
RELATED: Illumina posts new sales records, lays out long-read chemistry plans at JPM 2022
PacBio’s Henry also responded to announcements earlier in the conference from the company’s main DNA sequencing competitor—and one-time suitor—Illumina about its plans to add longer-read capabilities to its currently installed base of short-read machines.
Code-named Infinity, Illumina’s upcoming library prep system will alter samples with the goal of delivering contiguous data up to 10 kilobase pairs in length. The aim is to help sequence the remaining sections of the human genome that have posed obstacles to the company’s hardware in the past.
It’s a daunting move, with Illumina commanding about 75% of the global DNA market and an installed base of at least 20,000 machines among its more than 8,000 customers—none of whom would have to purchase new sequencers to upgrade the read length of their current hardware. The news sent PacBio’s stock down about 15% the morning after the announcement.
“The challenge with this approach is that it’s been tried several times and never really gained any traction, so it will be interesting to see how well it does,” Henry said. “The applications are probably more in bacteriology and some of those smaller genomes.”
“You’re still fragmenting the DNA, and you’re still losing information that you couldn’t get,” he said, comparing it to PacBio’s sequencer reads that average between 10 and 25 kilobase pairs. “There’s some real limitations to what stitched short reads can do, but it demonstrates the fact that competitors believe that long reads are important.”
RELATED: PacBio nets $900M from SoftBank to support its long-read sequencing goals
Henry also delivered a preliminary look at the company’s 2021 financial report, which he described as the most productive year in PacBio’s history.
Product and service revenues estimated for 2021 came in at about $130.5 million, equaling 65% year-over-year growth compared to 2020’s $78.9 million and far outpacing 2019’s $90.9 million. 
Those numbers stem from an 84% increase in the company’s installed base of machines and 250% growth in the petabytes of data generated by researchers using PacBio hardware globally.
Looking forward, PacBio also announced a deal with Beijing-based Berry Genomics to develop its first small, tabletop-sized sequencing system, bound for the clinical market in China.
Berry Genomics will purchase at least 50 instruments at launch to expand its own footprint in perinatal and carrier testing and will also sell the instrument and consumables within the country. Berry Genomics previously supported the national regulatory authorization of PacBio’s Sequel II instrument in 2019.
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Carrots Have These 8 Amazing, Surprising Health Benefits



Initially, the vegetable originated in the geological area and the Asian United States, and it was initially only available in purple and yellow hues. Carrots are an excellent source of beta carotene, a natural mineral introduced by the body to provide sustenance, and they are high in fibre.

Carrots, which are crunchy, orange, and delicious, provide a variety of benefits to our health, pores, skin, and hair. These don’t appear to be particularly tasty, but they are loaded with numerous important nutrients, for example, beta-carotene, cell reinforcements, potassium, fibre, sustenance K, and so on.

Carrots are cultivated to promote eye health, lower dangerous LDL cholesterol, and aid in weight loss. Let’s put it to the test and find out why carrots are so good for you!

The following are twelve effective edges you might get from carrots:

1. Supports gadget

Most importantly, carrots contain a few phytochemicals that are well-known for their cancer-causing properties. Carotenoids and carotenoids are present in more than one of these associations. Overall, compounds create resistance and activate specific proteins that prevent the growth of most tumor cells. An investigation reveals on a screen that carrot juice can also fight leukemia.

2. Advances Glowing Skin

Investigate tips that stop outcome, and vegetables well off in those composites will finish pores and pores and skin ground and work with people’s appearances, thus making them more noteworthy young.

3. Fortifies Bones

Carrots are high in vitamins, minerals, and cancer-fighting agents. Vitamins B6 and K, potassium, phosphorous, and other minerals contribute to bone health, a more durable, and help with mental performance. Aside from selling the body to free extreme annihilation, cancer prevention agents keep an eye on the casing in the course of dangerous microbes, infections, and diseases. Physical cell digestion is managed by the ophthalmic component. Carotenoids have been linked to improved bone health.

4. Advances Male physiological circumstance (ED)

These fruitfulness meals may increase the number of sperm cells and their motility. According to research, this is a direct result of the fake carotenoids found in carrots, which are responsible for the vegetable’s orange color. However, it is still unknown whether carrots can improve sperm enjoyment and motility. Carrots are being tried to improve food for male physiological conditions and erectile dysfunction. Cenforce FM and Cenforce D can be used to treat impotency.

5. Keeps From Cancer and Stroke

Carrots have an unusual endowment in that they are loaded down with anti-cancer resources that will depress the cells’ blast. Essentially, studies have discovered that carrots can reduce the risk of a variety of diseases, including colon, breast, and prostate cancer.

6. Further develops the natural framework Health

Carrots contain a significant amount of dietary fibre, which plays an important role in supporting healthy stomach function. Fibre expands your stool, allowing it to pass more easily through the stomach-related plot and preventing stoppage.

7. Assists with managing polygenic affliction and basic sign

Carrots are high in fibre, which promotes cardiovascular health by lowering LDL cholesterol levels in veins and blood vessels. Calcium is absorbed through the frame of carrots, resulting in low but dangerous cholesterol levels.

Carrots have an unbalanced fibre content. An investigation found that advanced fibre consumption improves aldohexose digestion in people with the polygenic disorder. Following a healthy, well-balanced diet and maintaining a healthy weight can reduce the risk of type 2 diabetes.

Inconsistencies in glucose digestion may require a high level to combat aerophilic strain, and this is frequently where the inhibitor nutrients dilettanti ophthalmic thing axerophthol fats-solvent sustenance may also benefit.

According to one review, juice provided a 5 wrinkle inside the beat fundamental sign. The supplements in carrot juice, with fibre, K, nitrates, and vitamin C, have all been obtained to help this final product.

8. Advances Healthy Heart

To begin with, each cancer prevention agent is beneficial to your coronary heart. Furthermore, at 0.33, they should contain fibre, which can help you stay in shape and lower your chances of having a heart attack.

9. Forestalls devolution

Edges that are hostile to ophthalmic detail ensure the floor of the eye and provide a sharp inventiveness and perception. Taking juice will help to delay many eye diseases, such as macular degeneration, cataracts, and visual impairment. Overall, carrots contain lutein, which is an inhibitor that protects the eye from obliterating light.

10. Works on urinary organ and Liver perform

Carrots contain glutathione. Cell reinforcement has been shown to be effective in treating liver disease caused by aerophilic strains. The greens are high in plant flavonoids and beta-carotene, both of which stimulate and develop your popular liver component. Carrots contain carotenoid, which can help fight liver problems.

11. Palatable Anti-Aging

Along with carrots on your regular food, you will appreciate limiting the way you get more seasoned. Furthermore, beta-carotene functions as an inhibitor that advances cell harm, which happens as a result of the casing’s normal digestion.

12. Advances Weight Loss

Uncooked Carrots are 88% water when raw or ebb and flow. A regular carrot has the lowest difficulty level of 25 energy. Taking everything into consideration, including carrots in your diet is a wise way to fuel yourself while collecting calories.

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